The purpose of this paper is to examine the SSP paradigm in supply chain context. SSP is the central paradigm of the strategy literature. Current study designed to foster a better understanding of the impact of supply chain uncertainty on the elements characterizing strategic decisions that lead to improved supply chain structure and operational performance.In line with the previous research, this study also represents the empirical efforts to explore and test the relationships between supply chain uncertainty, strategy, structure and operational performance.This research seeks to advance our understanding on the application of SSP paradigm in supply chain context, by incorporating the impact of uncertainty. This is a very timely study due to the increased risk and vulnerability of supply chains to disruptions. This study highlights the nature of uncertainties and strategies to achieve a resilient supply chain network for a sustained operational performance.